The study's
international team developed a method to accurately and programmably control
the synthesis of viral capsids, the protein shell of viruses, in physiological
circumstances. This method was published in Nature Nanotechnology.
By using DNA 'origami'
templates, Griffith University researchers have significantly influenced how
viruses are constructed. The study's international team developed a method to
accurately and programmably control the synthesis of viral capsids, the protein
shell of viruses, in physiological circumstances. This method was published in
Nature Nanotechnology. The Griffith Institute for Drug Discovery's Dr. Frank
Sainsbury and Donna Mc Neale, who were a member of the study team, claimed the
experiment addressed the issue of inducing viruses to assemble on DNA folded
into various forms "like origami." "We achieved control over the
virus protein shape, size and topology by using user-defined DNA origami
nanostructures as binding and assembly platforms, which became embedded within
the capsid," Dr. Sainsbury added.
The enclosed DNA
origami could be protected from breakdown by viral protein coatings. The viral
proteins deposit on top of the various shape that is determined by the DNA
origami shape in this action, which is more like wrapping a gift. Additionally,
various virus proteins resemble various types of wrapping paper, which is
pertinent to the various applications of coated DNA origami. The creation of
new vaccinations and delivery systems would benefit from precise control over
the size and structure of viral proteins. But the available tools to
programmatically control the assembly process were difficult to come by,
according to Dr. McNeale. There method may be used to create RNA-DNA origami
structures as well as virus capsid protein units, opening the door for the
development of future cargo protection and targeting techniques.
To better understand how various viruses self-assemble and how they might be utilised to encapsulate various payloads, Dr. Sainsbury and his team are now working. This will give them the ability to create and alter new virus-like particles for a variety of purposes. As an illustration, they observed that a virus isolated from mice can transport protein cargo through hostile conditions and into a particular subcellular compartment in human cells. There is still a lot to learn about viruses given the vast design space that exists among those that could be used as carriers. We'll keep testing the limits of how virus-like particles can come together and learning what we can from employing them as drug carriers, vaccinations, and biochemical reaction vessels, added Dr. Sainsbury.
By using DNA 'origami'
templates, Griffith University researchers have significantly influenced how
viruses are constructed.
The study's
international team developed a method to accurately and programmably control
the synthesis of viral capsids, the protein shell of viruses, in physiological
circumstances. This method was published in Nature Nanotechnology.
The Griffith Institute
for Drug Discovery's Drs. Frank Sainsbury and Donna McNeale, who were a member
of the study team, claimed the experiment addressed the issue of inducing
viruses to assemble on DNA folded into various forms "like origami."
"We achieved
control over the virus protein shape, size and topology by using user-defined
DNA origami nanostructures as binding and assembly platforms, which became
embedded within the capsid," Dr. Sainsbury added.
The encased DNA origami
could be protected against deterioration by the virus proteins. The virus
proteins deposit on top of the varied shape that is determined by the DNA
origami structure, making this action more similar to wrapping a gift. And
different virus proteins are analogous to various types of wrapping paper,
which would be pertinent to various applications of coated DNA origami.
The creation of new
vaccinations and delivery methods would benefit from precise control over the
size and structure of viral proteins. "But current tools to control the
assembly process in a programmable manner were elusive," Dr. McNeale
added.
Our method also doesn't
have to be used with just one kind of virus capsid protein unit; it can also be
used with RNA-DNA origami structures, which will open the door for future
methods of cargo protection and targeting.
To better understand
how various viruses self-assemble and how they might be utilised to encapsulate
various payloads, Dr. Sainsbury and his team are now working.
 |
| Complexed 13HR |
This will give them the
ability to create and alter new virus-like particles for a variety of purposes.
As an illustration, they observed that a virus isolated from mice can transport
protein cargo through hostile conditions and into a particular subcellular
compartment in human cells.
There is still a lot to
learn about viruses given the vast design space that exists among those that
could be used as carriers. We'll keep pushing the limits of what can be learnt
from employing virus-like particles as drug carriers, vaccinations, and
biochemical reaction vessels, says Dr. Sainsbury said.
Citation- https://www.nature.com/articles/s41565-023-01443-x
Advertisement
Close